Ph.D. Staff Scientist (Job Code 2005-05EN): The successful candidate will join a team developing assays for quantitative analysis of proteins in biological samples using our proprietary technology for the analysis of single molecules. The applicant should have a Ph.D. in Biochemistry, Immunology, Biophysical Chemistry or similar, with 0 – 2 years postdoctoral research experience. Demonstrated capability to conduct quantitative analyses is a must, as are proficiency in procedures for protein detection, purification and analysis, and practical understanding of binding thermodynamics and kinetics. Experience in immunoassays, protein modification, fluorescence (spectroscopy and microscopy), single molecule detection, or enzymology is a plus. Experience in protein assay development, especially in a commercial setting, is especially desirable. Experience managing other researchers in small teams is a plus, as this role offers significant opportunity to develop as a group leader.

Ph.D. Staff Scientist (Job Code 2004-49RG): The successful candidate will join a team for development of multiplex analysis of complex biosamples using our proprietary GeneEngine technology. The applicant should have a Ph.D. in Biochemistry, Biophysical Chemistry, or similar with 0-2 years experience. Demonstrated ability to plan and perform complex multistage experiments is a must as well as basic laboratory skills: HPLC/FPLC, electrophoresis, etc. Experience in modification and cross-linking of proteins, fluorescence (spectroscopy and microscopy), single molecule detection, breadboarded optical systems, polymer physics, and immunoassays is a plus.

Ph.D. Staff Scientist (Job Code: 2004-45RG): The successful candidate with background in Biochemistry or Molecular Biology must have 2-5 years of postdoctoral or equivalent training, plus knowledge of protein engineering and DNA-binding proteins, especially restriction endonucleases. Desirable experience includes interactions of nucleic acids with proteins, thermodynamic and kinetic analysis of formation of biomolecular complexes, fluorescent labeling, field flow fractionation (FFF), and fusion with fluorescent proteins (GFP).

Research Associate II/III (Job Code 2004-52DC): The successful candidate will have experience in science and software development with the ability to excel in developing algorithms and software for the analysis of scientific experiments. The applicant should have the ability to understand the principles behind the analysis of DNA in U.S. Genomics’ GeneEngine, to work with a team of scientists to code software algorithms evaluating new processing techniques and then to assist in the development of end user applications. Experience developing MS Windows applications is required. A BS with 2-5 years experience or MS in Physics, Biophysics or Physical Chemistry. 2-3 years of experience in software application development. Candidates with an alternate balance of science and software development experience will be considered. SPECIFIC DUTIES: develop software modules and applications for real time experimental data processing in collaboration with other software development scientists. Transition scripted calculations to interactive applications. Analyze experimental data of DNA traces generated by U.S. Genomics’ GeneEngine and compare it to current theoretical models of polymer behavior, fluid flow, optics, and biochemistry. Opportunities for additional responsibilities commensurate with experience. SKILLS REQUIRED: Ability to develop scientific applications operating under MS Windows. Ability to create and modify C++ under Visual Studio.Ability to analyze new experimental data on the properties of DNA using existing software and add features to that software to support improved algorithms. Ability to understand basic phenomena occurring in the GeneEngine (biochemical affinities, physics of microscopic optical excitation and emission, laminar flow profiles, DNA stretching). Self-motivated with a desire to learn scientific and software techniques by working with an excellent team of software developers, scientists and mathematicians. DESIRABLE SKILLS: Combinations of the follow skills will be advantageous: An understanding of advanced C++ techniques, e.g. namespaces, templates, and STL. Experience in physics or biophysics; An understanding of optics, spectroscopy, fluid flow, biochemistry, or bioinformatics; Experience with real time signal processing, statistics, numerical analysis, and software version control; Experience with Perl, MATLAB, or Mathematica.

Scientist, Bioinformatics (Job Code 2004-47MN): The Bioinformatics group at U.S. Genomics is seeking a trained bioinformatics professional, with at least a master’s degree, with extensive experience in probe or primer design. A successful candidate will need a high level of programming facility, particularly in Perl or a similar language, since many scripts are typically needed to support the activity. A good understanding of the relevant thermodynamics would be a very big plus. The successful applicant should be able to work independently as part of a team. ***SUCCESSFUL APPLICANTS MUST INCLUDE AN INFORMAL COVER LETTER MENTIONING ASPECTS OF THEIR EXPERIENCE THAT ARE DIRECTLY RELATED TO PROBE OR PRIMER DESIGN. PLEASE INCLUDE DETAILS DESCRIBING THE CONTEXT AND THE METHODOLOGY AND/OR SOFTWARE USED.***

Scientist (Job Code 2005-01LN): The successful candidate should have a background in Molecular Biology, or Biochemistry holding a MS with 2 - 5 years of experience. Skilled in recombinant DNA technology, some bioinformatics software (vector NT1 or similar), PCR, electrophoresis, nucleic acid isolation, gel shift assays, siRNA knockdown, mammalian cell culture and transfections.

Field Applications Scientist (Job Code 2004-38SG): The Field Applications Scientist will be responsible for supporting pre and post sales activities within a defined geography. Working with collaborators and helping the sales force to launch U.S. Genomics’ single molecule detection platform—including instrumentation and reagents—will be the FAS’ priorities. He/She will work with minimum supervision and in tandem with sales people to give training, to answer technical questions, to troubleshoot, and to deliver presentations. The FAS will educate and support existing and potential customers by delivering scientific lectures or representing U.S. Genomics at scientific meetings and trade shows. He/She will establish and maintain a network of high-level customers and opinion leaders. Critical to the FAS’ success will be the maintenance of records detailing customer interactions. The FAS will also work closely with Marketing and R&D to test new product concepts, to introduce new products to the market, and to select alpha and beta testing sites. A Masters degree in Biological Sciences or Molecular Biology is required; a PhD in a similar discipline is preferred. A minimum of 3-5 years of research experience and knowledge of a wide range of molecular biology techniques including Western, Northern, and Southern blots, qPCR, microarrays, and ELISAs is required; experience with data analysis is highly desirable. Computer literacy i.e. experience with software used in microarray, qPCR, and image analysis along with the ability to understand high level experimental design will be an advantage. Excellent verbal, written, and presentation skills with the ability to discuss technical issues at all levels in an are necessary. Travel is required. Customer support and/or teaching experience are desired. Individuals with demonstrable success in launching new products, consistency in meeting sales targets, and experience driving team success will be considered. The senior sales representative will be expected to work closely with sales people, marketing and other internal resources, as well as collaborators to present U.S. Genomics’ offerings in a professional and ethical manner. Those candidates with an entrepreneurial and pioneering attitude will be best suited for this role. A competitive compensation plan--including salary, commission, and car allowance--will be provided.

Scientist (Job Code 2005-11JK): The successful candidate should have a BA/BS (5-7 years experience) or MS (2-5 years experience) in Chemistry, Biochemistry, Molecular Biology or related field. Experience with bioconjugation techniques and/or Biochemistry bench skills are highly desirable. Responsibilities include the development and optimization of DNA/fluorophore conjugation chemistries to be employed in novel biodetection assays. Experience with optics, microfluidics and/or DNA manipulation are also desirable. Excellent communication skills and demonstrated productivity in a laboratory setting are required.

Director of Advanced Platform Engineering (Job Code 2005-10SG): Lead a creative team of engineers to aggressively develop products which apply USG’ proprietary single molecule technology to the life science and diagnostic markets. The position will be responsible for all hardware aspects of product development, from initial specifications through feasibility prototypes to product launch. The position includes developing product specifications, managing USG’ team of electrical, mechanical and optical engineers and liaising with third-party consultants. The position is required to seek out and incorporate new technologies that will add value to USG’ products and reduce their time to market. The role also involves keeping the department trained on the latest design tools, ensuring quality and consistency of USG’ Single Molecule Biology products and consulting with other departments on internal projects. Some sustaining engineering and enhancements to existing products might also be expected. This position reports to the VP of Engineering and is located in Woburn, MA.
Educational & Experience Requirements